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Generic prednisone 20mg /kg twice a day with or without metformin 30mg/kg for 4 weeks the treatment of irritable bowel syndrome [12]. A trial using metformin 30mg/kg daily in children and adolescents (age 11-17 years). All but 2 children were discontinued; all did not achieve remission. The median duration was 4 weeks. A second trial using metformin 30mg/kg daily in children and adolescents (age 11-17 years). All subjects attained remission. Duration prednisone generic drug was 6 weeks [17]. A third trial using metformin 0.5mg/kg daily in adults, ages 18-65 years. Subjects were hospitalized for 3 weeks. All subjects met criteria for active treatment. One patient (patient #2) improved and had resolution of stool frequency and/or consistency and no further improvement occurred in 5 of 6 patients. a fourth trial, using 2g metformin 0.5mg/kg daily for 4 weeks in adults, ages 18-75 years, the mean reduction in stool frequency was 13, with 1 subject reporting a median improvement of 16 stool hours per day in his/her stool for 3 week periods (median duration, 24 hours). It is unclear whether the decrease was significant [21]. Metformin is also given with a liquid preparation called metapress with hydrochloride, which is similar to a laxative laxative. This method was previously used to treat inflammatory bowel disease. In this preparation, the patient takes 1 teaspoon 3 times a day in the early and mid morning, followed by another teaspoon 1 hour later which should be taken every hour (approximately 4-5 hours). The first dose is usually taken 1 hour before the first regular meal. It is assumed that the metformin metabolized to metadate [15]. In an open label trial which 50 patients with active ulcerative colitis were treated for 4 weeks with metformin 0.5mg/kg daily by a single-blind design, 8 of 9 patients experienced an improvement (improvement > 2 SD's on the colonoscopy [12]). It was suggested that metformin did not interfere with the absorption of nutrients in intestine and did not reduce the absorption or appearance of stool [19]. Sodium bicarbonate In a trial with 20 patients refractory acute colitis, sodium bicarbonate (0.5 to 1g) twice daily at bedtime for 6 to 12 weeks resulted in complete resolution of symptoms. No clinical or endoscopic changes were observed in 6 of patients. Two patients experienced an apparent increase in serum lactate, but this was not confirmed and considered to be clinically meaningful [19]. Sodium citrate In a study with 10 adults severe ulcerative colitis and no response (3-6 month treatment), 5 patients (10%) were treated with sodium citrate 1 to 2g/day for 6 months with a 2 hour interval between doses [12]. Patients experienced symptom relief and improvement in bowel frequency consistency. The longest treatment period was 9 months when patients received 7g/day with 4 hours of interval between doses. Acidified Bicarbonate A study using similar protocol as sodium citrate with a lower dose of 1 to 2g twice daily at bedtime for 6 months resulted in complete resolution of symptoms. This is believed to be a buy generic prednisone online clinical relevance of the effects acidified form bicarbonate on the colon [19].
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